General Information

  • ID:  hor004024
  • Uniprot ID:  A0A0L0CIT3
  • Protein name:  CAPA-Pyrokinin
  • Gene name:  NA
  • Organism:  Lucilia cuprina (Green bottle fly) (Australian sheep blowfly)
  • Family:  Pyrokinin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Lucilia (genus), Luciliinae (subfamily), Calliphoridae (family), Oestroidea (superfamily), Calyptratae, Schizophora, Cyclorrhapha, Eremoneura, Muscomorpha (infraorder), Brachycera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  NA

Sequence Information

  • Sequence:  TGPSATTGVWFGPRL
  • Length:  15
  • Propeptide:  MKSFNSVDFVMCSLVVIAIVGSSKAELEQTKNRRGGGGSSGLFAFPRVGRSDPSLNINNLHNPDVTADNAAAAAAAALDVLYPSSSFEEYEEYPKSDVKRGGLIAYPRIGRSDADVRKWARLMALQQALDKRTGPSATTGVWFGPRLGKRSVDNQQYEKPSGQKEEY
  • Signal peptide:  MKSFNSVDFVMCSLVVIAIVGSSKA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-A0A0L0CIT3-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor004024_AF2.pdbhor004024_ESM.pdb

Physical Information

Mass: 179663 Formula: C71H107N19O20
Absent amino acids: CDEHIKMNQY Common amino acids: GT
pI: 10.55 Basic residues: 1
Polar residues: 7 Hydrophobic residues: 5
Hydrophobicity: -0.67 Boman Index: -713
Half-Life: 7.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 52
Instability Index: 582.67 Extinction Coefficient cystines: 5500
Absorbance 280nm: 392.86

Literature

  • PubMed ID:  23280433
  • Title:  Neuropeptidomics of the Australian Sheep Blowfly Lucilia Cuprina (Wiedemann) and Related Diptera